Non-Invasive Disease Monitoring Breath-Based Diagnostic Device Utilizing Breath-Sensing Nanotechnology with Precision and Accuracy

Bassel Alnajem 1,2 & Ahmad F. Turki 2

1. King Abdulaziz and his Companions Foundation for Giftedness and Creativity, Riyadh 11372, Saudi Arabia
2. Electrical and Computer Engineering Department, Faculty of Engineering, King Abdulaziz University, Jeddah 21589, Saudi Arabia, Centre of Excellence in Intelligent Engineering Systems, King Abdulaziz University, Jeddah 21589, Saudi Arabia

Poster PDF

Breathomics, an emerging field exploring volatile organic compounds (VOCs) shaping distinct breathprints for disease diagnosis, seamlessly integrates cutting-edge gas sensor technology and machine learning algorithms to introduce the Morbometer—a revolutionary breath-based diagnostic device. Utilizing sensor arrays and advanced data analysis, the Morbometer identifies specific VOCs in exhaled breath, surmounting challenges related to adherence and standardization. An innovative nano-gas-sensing array is envisioned for future iterations, enhancing functionality through algorithmic techniques, aligning the device with the evolving landscape of medical diagnostics. Through validation with real-world patient data, the Morbometer transforms disease detection, offering a non-invasive, user-friendly, and precise tool poised to reshape healthcare practices and empower individual well-being.

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Comments

16 comments
  • Excellent work. What's the benefit of using multiple sensors at the same time?

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  • Great work!

    I like it.

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  • What are some future directions for the development of the Morbometer?

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  • What are the various gases that are expelled in breath and what are their correlation to certain diseases?

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  • An innovative idea for improving patient health care especially for treatment of medically compromised conditions such as DM.

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  • We appreciate your question inquiring about the benefit of utilizing multi-sensor arrays. A person’s health can be examined through the volatile organic compounds (VOCs) they exhale. Our system can target specific exhaled molecules selectively because nano-sensing arrays can differentiate between different expelled compounds, which is critical for breath-based diagnostics. This technology captures the volatile properties present in breath, establishing nano-sensing arrays as fundamental components for ensuring versatility, efficient data acquisition, and validation. As a result, our device, the Morbometer, achieves high diagnostic accuracy.

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  • We value your question regarding the future directions we aim to expend with the development of the Morbometer device. One of our main goals is to fabricate a selective, multi-directional nano-gas sensing array for the discerning of specific compounds exhaled in breath. We also aim to incorporate algorithmic AI-enhanced techniques for the optimization of our proposed Morbometer device. While our current proposal seems to focus on diabetes, the future vision is to facilitate the diagnosis of a range of morbidities, including metabolic, infectious, and respiratory diseases, making the Morbometer a highly versatile diagnostic tool. We also aim to ensure our device’s efficacy and reliability through real-world patient examples, assisting in the refining of data features and extraction techniques.

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  • Amazing work. What is the impact of the proposed Morbometer breathalyzer device?

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  • Great work! Do you think that the proposed Morbometer could be employed to test for/measure specific cancer markers in exhaled breath condensate (EBC) similarly as in regular exhaled breath?

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  • It is really a great invention since it helps people detect whether they have diabetes or not in an easy way.

    It can also be developed to be useful for other kinds of diseases.  

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  • Excellent work !! Why are you planning on using nanotechnology in future iterations of your proposed device? What specific nano material composites are you looking forward on investigating?

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  • That's Amazing.

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  • I appreciate your nice remarks and well-considered inquiry. With its electronic nose (e-nose) and sensor array, the proposed Morbometer breathalyzer seeks to usher in a new era of non-invasive diagnostics by identifying particular volatile organic compounds (VOCs) in exhaled breath. Electroacoustic and metal-oxide gas sensors ensure a high signal-to-noise ratio (SNR) in order to provide accurate readings. Early identification of conditions like diabetes and metabolic disorders can result in prompt treatment and improved outcomes for patients. Cross-selectivity and virtual array capabilities make the Morbometer a quick, easy-to-use, and reasonably priced diagnostic instrument. Employing the Morbometer's actuator features and looking at breath trends, we can enhance patients' health care and management, leading to better outcomes.

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  • Your question about the applicability of our proposed device for the detection of cancer signature molecules is much appreciated. Based on the principles of the Morbometer, it is plausible to employ it for the detection of specific cancer markers in exhaled breath condensate (EBC). The volatile organic compounds (VOCs) present in EBC might offer insights similar to those in regular exhaled breath. In-depth assessment and validation—despite this—are essential.

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  • Thank you for your insightful question! We are planning on using nanotechnology in future iterations of our device due to its potential to enhance sensitivity and selectivity in detecting volatile organic compounds (VOCs). Nanotechnology allows for the miniaturization of sensor components, leading to faster response times and improved detection. The specific materials that will make up our intricate nano-sensing array will be composed of a wide range of different metal oxides, such as Cu-doped p-type ZnO nanostructures, SnO2 nanosheets with 101 crystal facets, and Rh2O3 NP functionalities electrospun WO3 nanofiber, all of which have been proven for their transducer-sensitive properties.

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  • That's an intriguing research topic and rather amazing.

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