SARS cov-2 infection screening via the exhaled breath fingerprint obtained by ftir spectroscopic gas-phase analysis. a proof of concept

Johannes Glöckler (1), Boris Mizaikoff (1, 2), Lorena Díaz de León-Martínez (1)*

(1) Institute of Analytical and Bioanalytical Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. 

(2) Hahn-Schickard Institute for Microanalysis Systems, Sedanstrasse 14, 89077 Ulm, Germany. 

Poster PDF

The COVID-19 pandemic remains a global challenge now with the long-COVID arising. Mitigation measures focused on case counting, assessment and determination of variants and their likely targets of infection and transmission, the pursuit of drug treatments, use and enhancement of masks, social distancing, vaccination, post-infection rehabilitation, and mass screening. The latter is of utmost importance given the current scenario of infections, reinfections, and long-term health effects. Research on screening platforms for COVID-19 has been developed to provide more sensitive, specific, and reliable tests that are accessible to the entire population and can be used to assess the prognosis of the disease as well as the subsequent health follow-up of patients with sequelae of COVID-19. The aim of the study was the simulation of exhaled breath of COVID-19 patients by evaluation of three identified COVID-19 indicator breath biomarkers by gas-phase infrared spectroscopy as a proof-of-concept principle for the detection of infected patients’ exhaled breath fingerprint and subsequent follow-up. This study proves the fundamental feasibility of gas-phase infrared spectroscopy for fingerprinting lung damage biomarkers in exhaled breath of patients with COVID-19. This analysis would allow faster and cheaper screening and follow-up of infected individuals, which could improve mass screening in POC settings. Also we are presenting here a new project insight based on VOCs detection in exhaled breath by means of new developed technology which includes VOCs sensors + gas-phase infrared spectroscopy to monitor long-COVID in POC scenarios. 





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