George Hanna - Challenges in external clinical validation studies
Professor George Hanna is the head of the Department of Surgery and Cancer at Imperial College and Consultant Upper Gastro-intestinal surgeon at Imperial College NHS Trust. He was trained in Ninewells Hospital, Dundee, Scotland and obtained a PhD (University of Dundee) in 1997 and FRCSEd (Gen Surg) in 1993. He joined Imperial College as a Clinical Senior Lecturer and Upper Gastrointestinal Consultant Surgeon in 2003. His clinical work is based at Hammersmith Hospital and includes oesophageal and gastric cancer and advanced laparoscopic surgery.
Professor Hanna leads the NIHR programme for point of care diagnostics in cancer and gastrointestinal diseases (NIHR London IVD). The current interests of his laboratory revolve around volatile organic compounds analysis for biomarker discovery and understanding the molecular drivers of volatile compounds to develop a non-invasive breath test to diagnose oesophageal and gastric cancer. His educational research aims to develop competency assessment tools for training and quality assurance of surgical performance in randomised controlled trials.
The breath field research has many small scale discovery studies that lacks external independent validation. The clinical environment and quality control demands present a set of challenges that need to be taken into consideration in the design and execution of clinical studies. Wide-scale studies, quality control measures and the design for external validation will be discussed.