Profiling Volatile Organic Compounds in Exhaled Breath by TD-GC-TOF MS

Profiling Volatile Organic Compounds in Exhaled Breath by TD-GC-TOF MS

Laura McGregor, Anthony Buchanan, Aaron Parker, Bob Green and Nick Bukowski

SepSolve Analytical, 22 Commerce Road, Lynch Wood, Peterborough, PE2 6LR, UK

 

Full poster:

http://ow.ly/Hiez30mqQVR 


 

 

Abstract:

The accurate identification and measurement of biomarkers in human breath has the potential to flag a range of physiological and pathological conditions. To identify biomarkers in breath it is essential that sensitivity is maintained whilst recording full spectral information. Pre-concentration techniques using solid adsorbents to entrain exhaled breath followed by analysis by thermal desorption–gas chromatography–time-of-flight mass spectrometry (TD–GC–TOF MS) can provide the required sensitivity for both targets and unknowns.

In order to link exhaled substances to diseases, it is important that trace VOCs are reliably identified and accurately measured. In this study we use an innovative TOF design that produces ‘classical’ spectra, allowing direct comparison with established commercial or user-created libraries. Novel data-processing software is also demonstrated that allows real-time background subtraction, deconvolution, library-searching and comparative analysis.

 

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