How relevant do you think in vitro VOC studies are to helping us understand VOC biomarkers on breath?

Limitations on clinical studies caused by the COVID-19 pandemic led some researchers to focus on in vitro studies to progress their work on VOC biomarkers. Several presentations at the Breath Biopsy Conference 2021, including those by Guido Verbeck and Giuseppe Ferrandino looked at results from in vitro studies.

In your view, how can in vitro studies complement breath research, and how can they best be used to help identify, develop and validate breath biomarkers for clinical use? What factors should we consider in the breath research field when comparing or extrapolating in vitro to in vivo data?



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